Enhancing human hematolymphopoiesis and especially T-lymphopoiesis remains an important goal for optimizing the current humanized immunodeficient mouse models. Yang’s team reports an improved human fetal thymus/liverimplanted immunodeficient mouse model in which a striking increase of the overall hematolymphopoiesis with significantly enhanced immune functions can be achieved via a simple intravenous infusion of autologous human fetal liver CD34+ cells.
Xenograft models provide a valuable system for evaluating physiologic functions of human cells in both basic research and preclinical settings. In contrast to large animals, mice with a severe combined immunodeficiency (Prkdcscid, or SCID) mutation1 resulting in lack of both T and B cells are much more commonly used due to their easy accessibility, cost-effectiveness, and feasibility of backcrossing with other immunogenetic mutations to further knock down innate immunity. Since the initial generation of SCID mice, a number of improved strains, such as nonobese diabetic Continue reading »
May 07
Powered by
Recent Comments