The syphilis is a kind of classic sexually transmitted disease .According to cure a historiography house to research, the syphilis originates America, 15 centuries, Columbus after discover the New Continent passes seaman and soldier to make syphilis at Europe and Asia two continents quickly spread.16 centuries ago, the our country still had no jot down of syphilis.About in 1505, the syphilis is streamed into Ling in our country Guangdong south by India on take, called “Chuang in Guangdong”, “red bayberry Chuang” at that time, henceforth the syphilis spread toward the hinterland.The ancients Chen takes charge of into Zhao 《mildewed Chuang the Mi record 》BE an our country the first treatise syphilis most perfectly and particularly Zhao, Ming Dynasty Lee Jean Zhao 《Chinese Herbal Materia Medica 》jotted down syphilis in detail popular circumstance.The syphilis is at the earliest stage taken into the our country in 16 jerkins by Portuguese of and the ancient times called venereal disease, red bayberry Chuang, mildewed Chuang, Hui Chuang…etc..After found a nation, the syphilis once was once exterminate in the our country, in recent years, along with outward communicate of multifarious day by day, the outbreak rate of syphilis also presents up-trend.
The syphilis is cause by the syphilis helicoid(pale helicoid), the course of illness is endless after fall ill, infringed upon genitals and skin in early days, the later period infringed upon each organ of whole body, and livinged varied symptom and body to advertise for, the pathological changes almost canned involve in whole body a dirty machine.The syphilis passes sexual behavior and can spread mutually in the crowd, and can be infect by the mother to the embryo, endanger the next generation.The very few few suffererses pass kiss and breast feed, connect to have the patient’s daily thing of the contagion damage but infect.In sex the dissemination the disease, the on the sick list number of syphilis is low, but long because of its course of illness, bane big, should to value.
The syphilis is the mankind’s infectious disease, the animal nonexistent syphilis helicoid inside the body, so syphilis the sufferer be the only infection source of this disease.Pass a sexual behavior infection in the dissemination process of syphilis, has 95% around, the very few few patientses are the secretions which passes to get in touch with a sufferer, or close of living contact, blood transfusion, breast feed etc. the path contract disease.After generally thinking occurrence gestation for 4 months, the syphilis accidentally can pass to get in touch with the sufferer once used of daily thing but is dye.Kiss, the breast feed and infant be born through produce an etc. all can infect.Moreover can pass clothes, towel, razor, cutlery, cigarette holder, sheet, bed sheet, doorknob, the sit type infections such as urinal and medical treatment apparatus etc..In early days syphilis sufferer its focus of have in the secretion a great deal of syphilis helicoid, therefore the contagion was the most strong.Pass sex life, these cause physique in the secretion directly infect to the other party.The human body has no inborn immunity dint to the syphilis disease, so the syphilis helicoid of very few quantity can cause the other party fall ill.Moreover, the pregnant woman which suffers from syphilis can pass a cause body an embryo through a placenta and cause the embryo’s congenital syphilis.General gestation congenital syphilis means that it can cause child syphilis through an infection inside the foetus, 9 week, embryo the ability be infect.The syphilis can cause the damage of the child each organ of whole body and organization and result in function obstacle or death.The prevention of inborn syphilis is mainly the penicillin that the mother uses amount of foot to cure of rear can gestation.
Generally speak, suffer from syphilis of first the contagion inside 1~2 years be stronger, an expect, two expect of the syphilis sufferers all have contagion and their skins glue film damage existence a great deal of syphilis helicoid;The syphilis sufferer who incubates earlier period also has contagion.Along with the extension of the disease period, the contagion of the syphilis also lets up gradually, when the course of illness is above over 2 years, the contagion of the syphilis will die down gradually, even with once hadn’t yet a treatment of course of illness the above syphilis women have sex contact in 2 years and generally can’t be infect, either.Course of illness over 8 years, its contagion already smallest.The human body doesn’t have inborn immunity dint to the syphilis, only at the existence syphilis helicoid inside the body then can produce the immunity dint which gets sick to this.Once curing a syphilis helicoid behind from the body inside disappearance, the immunity dint also immediately disappears and meet a syphilis helicoid an infection again, still keep suffering from a syphilis disease.
The syphilis helicoid(Tre-ponema palidum) is in 1905 discover by French scientist Schaudinn and the Hoffmanu and report.The syphilis helicoid(like diagram) is a small and slender spiral form microorganism, the length is a 5-20 nms, average about the 8-10 ums, the diameter is small at the 0.2 nms and have 6-12 helixes;The naked eye could not see, under the light mirror dark visual field, people only can see the fold of syphilis helicoid light and its activity is stronger.There are 4-6 whip hair the kind thin fibers in its head tie, its bitter end presents a curl form.At don’t under the influence of outside factor, spiral is regular.Because it is transparent to don’t easily apply color, and then call that it is a pale helicoid.The syphilis helicoid is disgusted with oxygen germ, can exist to breed over a long period of time in the body, only the condition be feat and then take the crossing crack method penny as two of carry on breed.Syphilis helicoid outward the resistibility of boundary be very weak, to chemicals also very sensitive, don’t easily exist outside body, boil, dry, soap water and general disinfection very and easily kills it and sunlight irradiation and dry environments all can make it die very quickly.The syphilis helicoid exists outside human body generally super however 1~2 hours.It can exist for few day under the environment of anoxia, can also survive on the damp clothes for few hour, generally can survive in the blood bank for 24 hours.The syphilis helicoid doesn’t bear heat, 40 ℃～s 60 ℃ can die for 2~3 minutes, 100 ℃ instant death.Can to its weakness exterminate a syphilis helicoid.Such as put a clothes at the bottom of the sunlight to insolate, put in the environment of aridity to store;Boil the tools and implements disinfect or uses chemistry thing disinfection, can kill to put out a syphilis helicoid and obstruct it of dissemination.
The dissimilarity gone by way of according to the syphilis infection can is divided into syphilis(acquire sex syphilis) and inborn syphilis in the day after tomorrow.(the foetus spread syphilis)The different stage which acquires sex syphilis according to the pathological changes development among them is among themdivided into syphilis(include a period syphilis with two period syphilis) and later period syphilis in earlier period again.(namely three period syphilis)
Appear for the outside private parts while expecting the main characteristics of syphilis(Primary syphilis) of have no pain to descend Gan.(hard descend Gan hard chancre)After have sexual intercourse, the syphilis gets into a body, propagate in the part first and cause burning disease gradually, then get into lymphoid tube, can immediately dip into in few hours neighborhood of lymphoid knot, get into blood to go, after several ten hours namely can appear in the marrow, spleen, testicle…etc., spread over whole body very quickly everywhere.General at not the Jie have sexual intercourse after 10~60 day, average for be taken bad for 21 days.Appear one dark and red spot papula or the grain of rice all of the erythemas in the outside private parts while start, hereafter swell up, become a bean greatly to the finger big and hard knot, after its papula surface debauched, become the form shallow ulcer, have syrup the liquid to leak out.This kind of which ulcerates general diameter in 1~2 Li rices, the list hair, circular or oval, slightly Gao Chu Pi2’s noodles, the boundary is tidy know, the edge is convex since, the quality is hard and solid, so call hard descend Gan, call early Chuang again.(like diagram)The base department of ulcerate sweep have no Nong liquid, can have a little amount syrup liquid leak out, leak out a thing little, leak out to have in the thing a great deal of syphilis helicoid.Leak out the thing prints a slice of dark visual field microscope a check it is thus clear that most helicoids.The male is hard to descend Gan mainly on the outer skin, coronal ditch, strap and the glans penis;The male of the homosexuality is familiar at the ass, anus tube or the rectum.The female is hard to descend the good hair part of Gan in the big labium, small labium, clitoris, the vagina ex- court, cervix etc., occurrence in these part have above 95%, the lips, breast of the ass, etc. the part sometimes also takes place.The early Chuang is the earliest skin to injure after the infection human body of the syphilis helicoid, it occurrence of the part is a syphilis helicoid incursion of part.Accept the anti- plum of not enough quantity a treatment or outside use a medicine treatment, it is thus clear that arrive not typical and hard descend Gan.Hard descend Gan to have no Yang to have no ache, have never touch as well pain, the quality is hard like cartilage, injure surface to sweep, not through cure 3~8 with in the week can from not stay scar formation or leave behind shallow form scar formation more, light the degree atrophy sex Ba or dye calm and steady.But this doesn’t mean that the syphilis has been completely recovered, but the incubation period stage which is placed in into the second period syphilis, through a period of time will get into two period syphilis.If this wishes to get to diagnose and well cure in time, can quickly attain to thoroughly cure of purpose, generally in good shape more behind.Hard descend Gan initial stage, the syphilis serum reaction of greatly parts of patients presents masculine gender, the masculine gender rate will increase Gao gradually hereafter, hard descend Gan to appear after 7-8 weeks, all patient’s serums respond for the masculine gender.
Often the companion has a stomach the ditch to pour flattering of have no pain swollen big.Hard descend Gan to appear the few day is behind, one side stomach the ditch be lymphoid to knot swollen big, another a side are also swollen greatly hereafter.These pour a flattering characteristics is:The ① is like finger size, harder, each other spread isn’t doing blend;The ② has no ache with press pain;The ③ surface skin have no red, swollen, hot etc. blaze disease phenomenon;④ Not maturation;The ⑤ wears to stab to have in the liquid a helicoid.The surface often presents meat red.The contagion of this period is very strong.
Syphilis helicoid from hard descend the lymphoid knot of Gan neighborhood into blood to spread whole body, general the occurrence infect behind 2-3 months or hard descend will get into for 6~8 weeks after the Gan disappearance two period syphilis.The syphilis helicoid that is at this time already through the blood circularly sow to spread to arrive each organization of whole body organ almost, appear the whole body syphilis rash, and can cause joint damage, eye pathological changes, central nervous system system to injure etc..Two expect syphilis is the most active stage in the syphilis course of illness, the contagion is strong.
The symptom of two period syphilises:
(1)the skin glue the damage of film:80% patients with 95% ～s can appear.Deliver to often have headache and have fever, swallow a pain, whole body before the rash unwell, muscle and joint are aching and are disgusted with a food etc. the importance different whole body symptom.The extensive occurrence is a lot of at the number of the syphilis rash of whole body, torso, arms and legs, face, Zhang Zhi department etc. many parts all can dense emergence.The appearance of skin rash is varied(rose spot rash, spot papula, papula, the scale urine papula, seldom seen hair bag burning kind or Li hull kind injure etc.), aware of self symptom slight, present whole body symmetry distribute, have no fusion incline to, state clear, present a copper red, generally not Yang or accidentally have slight Sao Yang, not painful.The serum reaction presents strong masculine gender.During the period of delivering a rash would also the companion have whole body the shallow form to pour to flatteringly have no pain swollen and big.
The rash appearance mainly has the following a few kinds:
Class the type of the rash:This type of familiar.Main cent near carry seamy side in the torso, arms and legs.The size of skin rash not etc., have another is the erythema of 1-4 Li rices diameter size, often is oval or circular, copper red, state clear, natural fade away.
Papula type:This type of easily familiar.Rash invite the grain of rice, soybean arrive nail size, solid, gradually obvious, present a copper red, state clear, have of the surface have scale scraps, is similar to psoriasis, bend of torso, arms and legs and Zhang Zhi’s etc. much sees.
Abscess type:This type of seldom seen.Much take place a weak patient at the body, the whole body symptom is more heavy.The Chuang kind, Li hull of the skin rash performance similar Cuo Chuang, pox kind and deep Nong pimple the kind of the rash, more behind leave behind scar formation.
Flat even and wet You type:The occurrence is at the skin rash mostly flat even and wet You or wet papula of ass surroundings and outside private parts.The flat even and wet You belongs to a wet papula type a syphilis rash.The good hair glues a film to hand over the part that boundary or skin easily rub at the skin, like size labium, anus week, anus periphery, inside outer skin, the seamy side, armpit, breast be inferior.The wet papula blends each other and present to swell up surface flat, sometimes present You form or nipple form, the surface is wet lousy, a great deal of exudation liquid contains a syphilis helicoid.
Take off hair style:Often is take place in the Nie Mao department skin of head hair bag surroundings, appear the center Zhu shed off of”the rat bite(eat by moth) a form” take off hair and fill the air sex seldom seen.
The syphilis white spot:There is dye disappearance, can keep on for few days.The syphilis white spot is a parts, such as mouth cavity, throat and genitals…etc. to glue film damage, external appearance mouth cavity beads the germ cause of goose the Chuang is the egg circular which slightly swells up damage, last Fu grey color film is red and dizzy, the Jie go to the base flush after the white film, don’t bleed.
Glue film damage:1 kind glues film swollen and inflamed, another is to glue a film to present the line debauched form, there is exudation thing condensing its surface formation ash white of glue a film spot.Glue the opportunity of film rash as well many, call to glue a film spot, is see in mouth cavity more, also it is thus clear that glue a film at the vagina, contain a great deal of helicoid.
(2)bone joint damage:Often- take place periostitis and arthritis.Because the syphilis helicoid infringed upon skeleton and bone joint to cause of, have no obviously burning disease phenomenon.The origin expects a characteristics for the ache to aggravate when evening and quiet take a rest, but in the daytime and activity lighter.Being take place in the long bone of arms and legs more may also is take place in adhere to of skeleton muscle some place, like Chinese foot bone eagle mouth, the Ka bone Mao and milk Tu.Have already increased play reaction when the first time accept a treatment.
(3)two period eye syphilis:Can cause an iris burning, the iris Jie form body be burning, see retina burning, choroid coat burning, see neuritis’ etc. is various eye diseases.
(4)central nervous system system damage:Have another is have no the symptom nerve syphilis, although have no symptom, the brain ridge liquid contain excrescent variety, such as the egg white increase, lymphoid cell number increment, the brain ridge liquid VDRL experiment masculine gender, the gum body gold curve unusually waits.The pole a handful of men has meningitis symptom, Lu nerve to paralyze, cerebral syphilis and the meninges afferent syphilis etc..
Two period syphilis sufferer’s skin rashes even not through treatment, also the ability fades away by oneself in few week or 2~3 months.Because cure ill success and cure to use a medicine quantity shortage or patient immunity dint to descend, about 1/4 patient’s symptoms can relapse again after fade away, for two expect to relapse syphilis(like diagram), generally take place in 1~2 years after infect.Can there is skin gluing film, eye, bone and internal organs damage to relapse, the most familiar glue a film to relapse for the skin, its damage with two period syphilis big body likeness, but the number less of skin rash, distribute to relatively limit, incline to of swarm compare two period more obvious, destructiveness more big, like hair in anus week, Qi nest, armpit, private parts, and Zhang department.The serum relapses most for much see.Serum’s relapse is the omen that the other relapse.Usually have serum first to relapse while canning have no other symptoms, but have an other to relapse when the serum relapse.
In fine, two expect the main performance of syphilis can generalize to three characteristicses:Type common cold symptom, syphilis rash and whole body be lymphoid to knot swollen big.Obviously painful because of have no while suffering from a syphilis rash, drive often easily the sufferer neglect.Clinical top if see distribute extensively, symmetry, but aware of self the symptom slight skin rash, will inquire the history of disease in detail, the in order to prevent leaks to diagnose.Two period syphilis the surface syphilis of the rash the helicoid be a lot of and therefore the contagion be the also the most strong.
Three expect the syphilis that the syphilis calls a later period again, much haven’t yet a treatment or cure ill success a development for the syphilis in earlier period but become.Can take place is above after infect for 2 years, generally and much deliver in infection after 3~4 years.The course of illness is endless, can keep on for 10~30 years.Haven’t yet healing of two expect to have around in the syphilis 1/3 of the patient can develop into movable sex syphilis in later period;Have another a part of sufferers don’t appear the syphilis symptom in later period, just the syphilis serum respond to keep on masculine gender, is later period incubate syphilis;There are also a part of sufferers from more.
In addition to injuring a skin to glue a film to cause syphilis knot stanza, resin swollen and near joint knot stanza etc. disease, the pathological changes can also infringe upon nervous system, cardiovascular and each internal organs, skeleton…etc. and cause later period cardiovascular syphilis, bone syphilis, internal organs syphilis, eye syphilis, and paralyze sex stupid, the meninges afferent syphilis, spinal cord Lao etc. nervous system syphilis disease.In order to knot the stanza skin rash or glue a film the performance of typical model, the skeleton resin is swollen, a handful of occurrence iris Jie form the body be burning, see a diagram film burning, keratitis etc..There are 15% sufferers around infringing upon skin, soft organization and skeleton, there is cardiovascular 10%-25% invasion, 10% infringes upon nervous system and can cause the brain substantial virus can express to is stupid for measles.Spinal cord Lao can cause nerve to atrophy while seeing nerve to be subjected to infringe upon.Can result in physically disabled, the condition severity can endanger life.
The contagion of the later period syphilis die down.
Inborn syphilis:(the foetus spread syphilis)Syphilis helicoid through the placenta mother’s serum make womb inner tire the son infect.Is divided into two periods:
1)earlier period inborn syphilis:The age is young in 2 years old, early expect to incubate syphilis such as the earlier period inborn syphilis.
2)later period inborn syphilis:The age is old in 2 years old, incubate syphilis such as later period inborn syphilis and later period.
The main clinical symptom express:
A, permanent sex marking, is leave behind by earlier period pathological changes, have already had no movable sex, but need to be made sex.
Two, still have movable sex damage with the result that of clinical performance:Familiar have swollen big swollen materiality keratitis, nerve deaf, liver Pi, resin, periostitis…etc..
Main depend laboratory diagnosis, syphilis serology experiment, brain ridge liquid check.
Haven’t yet the syphilis women of treatment, if disease period already over 4 years, although pass sex contact have already had no contagion, the gestation still can pass an embryo, the disease period is more long and the contagion is more small.There is scholar think, suffer from the mother of earlier period(one period, two period) syphilis, if don’t carry on a treatment, have half the infant will take place a foetus to spread syphilis, another half is still birth or postnatal period soon namely die;The earlier period which hasn’t yet a treatment incubates the mother of syphilis, 20% of its infant is normal or healthy of, 20% is a death;40% spreads syphilis for the foetus;Having not yet the mother of the later period syphilis of treatment infant’s 70% can be normal or healthy, 10% spreads syphilis for the foetus, and the rest can be a still birth or premature infant.In early days inborn syphilis of clinical now in order to often be appear in postnatal period the 2-6th week, have already flowed Ti, stuffed-up nose, mouth cavity to glue film damage.Often there is more serious internal organs injure, the death rate is higher.Suffer from in early days the infant of congenital syphilis, generally and all had malnutrition, skin crease many, the serious presented an old man kind noodles to permit.Another is anemic is swollen with liver, Pi big.
The recessiveness syphilis calls latent talent syphilis again.Although the sufferer hasn’t yet treatment or treatment quantity shortage, clinical symptom and body advertise for disappearance, just syphilis serology respond still for the masculine gender, and sufferer have no can cause other diseases that the serology responds false masculine gender, the brain ridge liquid check also normally.
After infect course of illness in 2 years in is an earlier period incubate syphilis, in 2 years above then is later period incubate syphilis.Earlier period incubate the syphilis still have contagion and go to delitescence later period its contagion disappearance, but for the pregnant woman, the sufferer’s syphilis helicoid still can pass an embryo through a placenta.The recessiveness syphilis doesn’t is through treatment and 30% sufferers will take place the syphilis in later period.
[Clinical performance and diagnose important point]
1.a expect syphilis(hard descend Gan)
1)have not Jie to have sexual intercourse, the infection history or homosexual history of the Piao bawdry, spouse.
2)the incubation period be 2-4 weeks.
3)main performance for hard descend Gan, often for the single, have no pain have no Yang, state clear, diameter 1-2 Cm size, touch it such as cartilage kind degree of hardness, surface can debauched or shallow ulcer, the exudation has a great deal of syphilis helicoid in the thing.
4)often take place in the outside genitals part, such as the male’s coronal ditch, glans penis, strap and outer skin, the female’s big labium, small labium, temple neck etc. part, the male homosexuality can take place to in the anus week and rectum and accidentally be see in lips and swallow etc..
5)the part be lymphoid to knot swollen big, single side or double side.
6)not through cure 3-8 with in the week hard next dissolve can natural disappearance, not stay trace or only stay a light degree to atrophy sex Ba.
7)secretion Tu2 Pian4 make a dark visual field microscope a check, it is thus clear that the helicoid of most activities.The syphilis blood Jing experiment:Hard descend Gan earlier period feminine gender, greatly parts of sufferers present masculine gender a result after 7-8 weeks.
2.two period syphilises
1)many be taken bad for 6-8 weeks after the first time infect after 8-10 weeks or appear hard descend Gan.
2)main the performance glue film damage for the skin, can appear periostitis, joint pain etc. bone joint injure, iris burning, see neuritis etc. eye injure, accidentally see meningitis etc. nerve damage.
3)the appearance of skin rash be varied, such as the spot rash, spot papula, papula, Nong pimple rash, the scale scraps skin Sun…etc., often be suffused with hair, symmetry distribute.Occurrence’s palm tree copper color in the Zhang Zhi takes off the scraps spot papula to have a characteristic.
4)glue film damage it is thus clear that at the mouth cavity, swallow, the larynx, genitals glue a film, is red and swollen and debauched, at anus week, the outside genitals surroundings can take place flat even and wet You and glue to have a great deal of syphilis helicoid inside film damage.
5)skin of head it is thus clear that eat by moth take off of form hair, deliver a Nie department familiar.
6)whole body shallow form the lymphoid knot be greatly swollen.
7)glue film damage and secretion Tu2 Pian4 of the flat even and wet You to make a dark visual field microscope a check, it is thus clear that the helicoid of most activities, the syphilis serum experiments to present strong masculine gender.
Two expect to relapse syphilis:Two expect the syphilis to haven’t yet to cure or cure a think of ill success, be patient’s resistibility to descend dint, two expect the damage to re- appear after fade away, be called two expect to relapse syphilis, if incurable treat, many again and again, this rash is together basic two expect a syphilis rash, but its number reduce and distribute limit bureau.
3.three period syphilises(later period syphilis)
1)have not the Jie life or spouse infection history, in early days syphilis history not essential.
2)the skin glue film syphilis
Knot the stanza syphilis rash:Familiar descend sub-footing to slice for most skin at the ex- sum, arms and legs and shoulder etc., present a wreath form to arrange, natural fade away, leave behind to atrophy sex spot.
The resin kind is swollen:Beginning is a skin to descend small hard knot, gradually enlarge and glue with skin connect, formation gradually sex spot piece, the center breaks Kui formation ulcer, the good hair is at the head noodles and calf etc..When invade and separate to glue a film in the top Mao and nose, can result in to separate to bore hole in the nose and saddle nose.
3)cardiovascular syphilis:Take place after infect more than 10-20 years, can cause syphilis aorta burning, the aorta petal shuts a lock not whole, aorta lump etc..
4)nerve syphilis:Infect to take place after 5-15 years, can cause syphilis meningitis, spinal cord Lao and paralyze sex stupid etc., may also have brain ridge the liquid unusually changes, but impassivity system symptom.
5)other dirty machines:Like skeleton, eye, breath, digest and Bi urine the system all can be invade.
6)the syphilis serum experiment greatly part of masculine gender, there is minority may also feminine gender.
The brain ridge liquid white cell increase, bio-chemical check abnormality, the syphilis antibody experiment masculine gender.
4.incubate syphilis
There is infection history, haven’t yet a treatment or cure insufficiency, have no clinical symptom and body to advertise for, but the syphilis serum respond masculine gender, excepted other can cause syphilis serum to respond male disease, brain ridge liquid check feminine gender, can diagnose in order to incubate syphilis, the disease expects to be small in 2 years, calls earlier period incubate syphilis, big in 2 years call a later period incubate syphilis.
5.earlier period inborn syphilis
1)the natural mother get syphilis.
2)many appear clinical symptom after living for 3 weeks.
3)expressed for the rhinitis, relax throat symptom in early days, because the stuffed-up nose can make breast feed difficult.
4)the skin performance be diverse and injure such as the spot papula scale scraps, water pimple and big pimple and big pimple injure, flat even and wet You kind injure, quarrel, anus week can take place the line form Jun crack damage, skin stem wrinkly like old man, can the companion take off hair, A ditch burning, A bed burning.Have already glued a film spot inside mouth cavity.
5)suffer from son thin small, shallow form the lymphoid line be swollen big, the liver Pi is greatly also swollen, often have bone cartilage burning and periostitis.
6)the skin glue the secretion of film damage, nose secretion, cord blood Tu2 Pian4 makes a dark visual field microscope a check, it is thus clear that arrive helicoid, the syphilis serum experiment masculine gender.
6.later period inborn syphilis
Much take place at the child and the awkward age, suffer from son to have syphilis Chi(half month form front teeth), materiality keratitis and nerve deaf three allied advertise for, have a characteristic.The skin glues the film damage and the day after tomorrow three period syphilis likeness, can also appear periostitis, the liver Pi is greatly swollen to wait movable sex damage.
7.the inborn incubate syphilis
The inborn syphilis hasn’t yet a treatment, have no clinical symptom and the syphilis serum responds that the masculine gender calls inborn latent talent syphilis.
[The syphilis serum experiment]
1.the non- syphilis helicoid antigen the serum experiment:Work hard the Lin fat do antigen, check the anti- heart Lin fat fat antibody in the serum, then reaction vegetable, belong to this type of of experiment of VDRL experiment, the UST experiment and the RPR experiment, these experiment the method be simple, be easy to expansion, is a clinical in common use normal regulations experiment, can also at large-scale census use, in addition these experiment all can make a fixed amount measurement, can used for observing curative effect, judgment whether relapse and again infection, but should notice because of experiment the antigen right and wrong for use particularity of, as a result easily appear false masculine gender result, some infectious diseases are like the virus hepatitis, measles, upper respiratory infection, movable sex tuberculosis, oneself immunity disease hour all can appear false masculine gender result, but the serum respond of drop the degree be low and keep on time generally shorter.
2.the particularity antigen of the syphilis helicoid the serum experiment:Use live of or dead of syphilis helicoid or its composition to measure anti- helicoid antibody, belong to this type of of experiment and have the fluorescence helicoid absorb experiment;The syphilis helicoid blood Ning experiment:This type of the particularity for experiment is strong, can used to a confirmation experiment, but can’t used to observation curative effect, the judgment relapses and infects again.
[Cure]
Principle:As soon as confirming should in early days, foot quantity, the rule used a medicine treatment, after treat periodically with visit.
Cure the period shouldn’t have sex life.
Sex companion accepts a treatment in the meantime.
Cure syphilis to want according to early cure, the amount of foot use a medicine of the principle carry on.During the period of cure, the sufferer wants to notice a rest, strengthen nourishment and avoid sex life.
The penicillin chooses a medicine for the head which cures syphilis.
The basis is Chinese the health department hygiene epidemic prevention department 《sexually transmitted disease prevention and cure manual 》establishment of treatment project, concrete method as follows:
1.earlier period syphilis(a period, two period, earlier period incubate syphilis)
1)green toxin
The card of Pu Lu is because of the penicillin G:800,000 units, a muscle notes everyday, continuous 10-15 days, the total amount is 800112,000,000 units.
The Xia star penicillin G:(long effect west wood)2,400,000 units, divide two measure a hip muscle to note, once a week, total 2-3 times.Or 2,400,000 unit an a week total amount is 4,800,000.
2)to penicillin allergy
Erythromycin:500 mgs/day, 4 times a days, continuous 30 days.
Strong dint mildewed vegetable:The 100 mg 2 times takes orally continuously for 30 days everyday.
2.later period syphilis(include three period syphilises, two expect to relapse syphilis and later period to incubate syphilis)
1)penicillin
The Pu card is because of the penicillin G:800,000 units, a muscle notes everyday, continuous 15 days, the total amount is 12,000,000 units.Treat a distance for the second for partition 2 weeks, the total amount is 24,000,000 units.The Xia star penicillin G:2,400,000 units, every week-time the muscle note total 3 times.
2)penicillin allergy
Four wreath vegetables:The 500 mg 4 times takes orally continuously for 30 days everyday.
Erythromycin:Take orally every time 500 milligrams, 4 times connect to take for 30 days everyday.
Strong dint mildewed vegetable:Take 100 milligrams each time, 2 times connect to take for 30 days everyday.
3.the cardiovascular syphilis pay respects to the treatment of the syphilis in later period, can increase to treat a distance number when it’s necessary, but don’t apply the Xia star mildewed plain G.
The possible occurrence Ji sea for sufferer to cure responds separately
Should respond to fasten because of apply after the penicillin a great deal of syphilis helicoid death, the opposite sex egg white release with the result that, generally take place 3-12 hours are after injecting a green fungi city for the very first time, performance is the kind symptom of flu and original syphilis injure the palliation aggravate, this phenomenon occurrence, tasty aspirin O.6 gram, 4 times disappear for general 1-2 days everyday.May also start take orally to strongly loosen a 5 mgs a day before inject with cardiovascular syphilis to the nerve syphilis, 4 times can there is prevention continuously for 3 days everyday a function.
The disease expects over the syphilis(later period skin film, skeleton syphilis or disease expect and can’t make sure of incubate syphilis) for two years and two expect to deliver syphilis more:
A, the card of Pu Lu is because of the penicillin sodium:800,000 the units be continuous 15 days for a day.The total amount is 24,000,000 units.
Two, the Xia star penicillin sodium(long effect west wood)2,400,000 units divide on going to twice, once a week, total three times, the total amount is 7,200,000 units.
Three, penicillin allergy use erythromycin:The 0.5 gs takes orally each time, 4 times a days, take for 30 days in a row to a to treat a distance.
Cardiovascular syphilis
A, the card of Pu Lu because of penicillin sodium
Method of using:800,000 the units be continuous 15 days for a day.12,000,000 units for a treat a distance.The virus severity rests medicine both sides when it’s necessary three knife week the juniors go the second to treat a distance, can also give many treat a distance.
Two, penicillin allergy use erythromycin
Method of using:Every time 0.The 5 gs take orally, 4 times a days, take for 30 days in a row to treat a distance for 1.
Nerve syphilis
A, water help penicillin
Everyday 4,800,000 unit vein intravenous drop, 10 day for on treat rest the medicine repeats 1 again to treat for day.The total amount is 96,000,000 units.
Two, Pu Lu Xia because of penicillin
Method of using:Everyday 2,400,000 muscles note and take orally C Huang in the meantime comfortable, every time 0.5 gs, four times a days, total 10 days.Immediately after use the Xia star penicillin sodium every week 2,400,000 unit muscles to note, total 3 weeks.In order to avoid to living an outside, can be inject penicillin to start take orally the first 1-3 day strong loose, the 30-45 mgs is continuous 3-5 days everyday.
(1)the treatment of earlier period syphilis:(include one period, two period syphilis and course of illness in 2 years in of incubate syphilis)The Xia star penicillin G is 2,400,000 units and divide two side hip the muscle note and once totally use 3 weeks every week;Or the card of Pu Lu is because of the penicillin G, the muscle notes 800,000 units everyday, continuous 10~15 days, total the dosage be 8,000,000~12,000,000 units.
To penicillin allergy can choose to use erythromycin to take orally 500 milligrams each time, everyday 4 times, connect take for 15 days;Or the strong dint mildewed be plain to take 100 milligrams each time, 2 times connect to take for 15 days everyday.
(2)later period syphilis(include three expect a skin and glue a film, skeleton syphilis, the later period incubates syphilis or can’t make sure the recessiveness syphilis that the disease expect) and two expect to relapse the treatment of syphilis:The card of Pu Lu because of penicillin G the muscle notes 800,000 units everyday and connect to use 20 days;Or the Xia star penicillin G24 be 0 units, each muscle notes once and totally use 3 times.
The syphilis, nerve syphilis…etc. of cardiovascular system appeared to the syphilis later period should use a medicine under the doctor’s instruction.
The foetus spreads syphilis:
(1)the foetus spread syphilis in early days;The ① Pu Lu card is 50,000 us/kgs because of everyday of penicillin G, inject inside muscle, continuous 1 O day;The ② Xia star penicillin G is 50,000 Us/kgs and inject once inside muscle.
(2)the later period foetus spread syphilis:The ① Pu Lu card is 50,000 Us/kgs because of everyday of penicillin G, inject inside muscle, in a row on the 10th for 1 treat a distance.The ② Xia star penicillin is 50,000 us/kgs, inject inside muscle, once then.(shouldn’t exceed an adult to bigger child’s penicillin dosage for same period the sufferer’s treatment quantity)
Earlier period, later period foetus’ spreading syphilis to suffer from son can choose to use the erythromycin 7.5~25 mgs/kg to the penicillin allergy, take orally, 4 times/day
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