【Summary 】 purpose:the analysis extend a myocardial a disease(DCM) sufferer the serum TNF α a density a comfortable piece the relativity of the last phase capacity(LVEDV) with left room.Method:the choice DCM be sufferer’s 62, normal check-up 60 be matched controls and measurese the TNF α density and LVEDV.Result:DCM sufferer the TNF α level show Zhao to go up(P<0.05) and present with LVEDV just related.(r=0.763)Conclusion:DCM patient the serum TNF α density and LVEDV be closely related;The interaction of of twos may have an important function in the DCM outbreak mechanism.
【Keyword 】 extend a myocardial disease;The tumor bad cause of death son α ;Left room comfortable piece last phase capacity 07)
Extend a myocardial disease(dilated cardiomyopathy, DCM) is a kind of advanced case heart attack with unidentified cause of disease.Clinical top with heart extension, the heart Lyu disorder with Chong guts the mental exertion crock up(CHF) is main expressional original hair myocardial disease, up to now still have no thoroughly of treatment method, after prepare bad the ［ be one ］ .Tumor bad cause of death son(tumor necrosis factor, TNF) system, especially the TNF α be a kind of cell factor which has various biology effects.The recently research expresses that the TNF α participates a coronary, myocardial disease, mental exertion to crock up etc. various occurrence and development process of the heart paroxysm ［ be 2 ］s.The left room comfortable piece last phase capacity(LVEDV) is one of the index sign which reflects heart function, from the left room is in the comfortable pressure of piece last phase and make the degree decision of the heart extension in the certain pressure.Domestic and international concerning the TNF relation report between α and LVEDV the way be rare, the this research’s relation toward the TNF α level and the LVEDV carried on the study of first step, now report a way as follows.
One data and method
1.1
The DCM set is total 62, the average age is(42 ±s 14) a year old, among them male 32, female’s 30.Diagnosis standard press the standard diagnosis that the WHO/ISFC draws up in 1995, expel a coronary, high blood pressure heart attack, rheumatism heart attack, the infection film inside the heart burning.The matched control is 60, normal crowd, the average age is(41 ±s 11) a year old, among them male 29, female’s 31.2 sets all seek medical advice in my hospital and its age, sex difference all has no covariance to learn meaning.(P>0.05)
1.2 methods
Take time to the stomach vein blood 3 ml ～ 4 mls, leave the heart 10 mins(2000 rses/min) to take to load separately up the pure liquid under 4 ℃ , place in-the conservancy in 20 ℃ refrigerators need to be measure.The TNF α tries a box to present the limited company of the living creature technique to provide from Shanghai day, adsorb a method(ELISA) examination with the Mao allied immunity and strictly press the manual operation.Adopt the HP of Hui4 Pu3 company Sonos in the meantime 5500 super voice move the diagram examination LVEDV level, adopt heart point four chamber hearts and obtain comfortable Zhang Qi2 standard picture, from computer calculation.
1.3 covariances learn a processing
Adopt SPSS 10.0 softwares to carry on covariance to learn a processing, all count comparison adoption t to examine, and difference to two sets of TNF α , the LVEDV carries on relativity analysis.
2 result each measurement result, see table 1.The form 1 TNF α and LVEDV measurese the comparison of result(slightly)
3 discussions
TNF α mainly from list pit the be huge to bite cell to secrete, the cell of other types is like lymphoid cell, smooth muscle cell, become fiber cell etc. at must under the condition also have creation and release TNF the ability ［ of the α is 3 ］s.The TNF α is a kind of Cu burning sex cell factor, there is important function in the immunity the reaction, burningly the disease and the rightness the harm the reaction, main influence the cell propagate with the cell Diao regulate of Wu.TNF α not only has cell to the tumor cell the poison, cell to fuse, repress to propagate, induce cell Diao Wu etc. function, also influence the growth of various normal cells to divide, and become a complicated immunity network together with other cell factors.There is the myocardial cell of the research enunciation under the certain incitement condition recently, also have TNF the mRNA expression of the α and it protein of synthesize ［ 4, 5 ］s, and animal experiment express, make use of the TNF α single anti- to effectively moderate the blood plasma TNF α , can obviously reduce the myocardial Diao Wu amount ［ is 6 ］s.Discover through this research, DCM sufferer compared with the normal matched control, the TNF α level difference has covariance to learn meaning(P<0.05), and presents with LVEDV just related.TNF α’s this kind of variety in the DCM the sufferer the body inside expresses that the TNF α has already emphasized to want a function in it the outbreak the mechanism.But DCM sufferer the TNF in the body α’s go up be reason or result that the LVEDV go up, currently still not clear, calculate the TNF go up of α may go up with LVEDV to become vicious cycle mutually in certainly the scope, this research TNF α and sufferer LVEDV become just related may be one of the performance of this process.From here, we calculate TNF α further and may pass to induce the myocardial cell Diao Wu to cause the myocardial electricity machine activity change but produce obvious heart function obstacle end become an extensive myocardial to change sex, fiber to turn, heart chamber extension, the constringency dint descend etc., then help realize DCM formation.In fine, the DCM is many factor coefficient result, take TNF α as the representative’s burning disease factor have certain function, measurement TNF α for understanding the DCM sufferer’s pathological changes of the occurrence development have positive effect, but the TNF α go up of reason and concrete the function mechanism treat further research definitely clear
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