In great quantities clinical test a certificate with animal, many medium the herb medicine have to protect a liver function, but the University of Yanbian pharmacy hospital the herb medicine carries on protecting the liver medicine sieving work in the rightness 50 remainings the kind in stumble on, Fu basin grass with withered son, summer and Yin go grass’ etc. and can aggravate small rat CCl4(four chlorination carbons) sex liver harm.For solving these three kinds of toxicities of medicine materials, the researcher carried on these a medicine material water to lift a thing again to move to change Mao(ALT) and serum a day a door winter ammonia Ji to move an experiment of change the Mao(AST) influence to normally small rat serum C ammonia sour Ji.
The researcher is divided into small rat random medicine material set, medicine material+ CCl4 set, blank set and CCl4 set, each 12.The medicine material set and medicine material+ the CCl4 set use a medicine material water to lift a thing to infuse stomach(Q, 2 milliliter/10 grams of weights), everyday sooner or later one for each, continuous give medicine for 4 days, other 2 sets give together physical volume running water.After the 5th day infusing stomach for two hours, medicine material+ CCl4 set and CCl4 set belly cavity inject 0.1% CCl4 colorses pull oil aqua(O.1 milliliter/10 grams of weights) and the medicine material set and blank set inject together physical volume physiology brine.Take blood from the eye socket after 24 hours(take to forbid to eat for 12 hours before the blood), leave ALT and AST of the heart separation serum measurement.
Discover that Fu basin son and Yin went grass water to lift a thing and don’t show a Zhao function to the small rat ALT and the AST as a result, but summer withered grass water lift a thing to make small rat ALT the value obviously goes up(P<0.05), and make the AST value go up to show Zhao very.(P<0.01)Fu basin son+ the CCl4, Yin go grass+ the CCl4, summer withered grass+ CCl4 and CCl4 set ALT value and AST be worth to all compare the blank set obviously goes up(P<0.05~0.01), and Fu basin son+ the CCl4, Yin go grass+ CCl4 and summer withered grass+ to compare with CCl4 set, CCl4 set ALT and AsT be worth to also have to obviously heat up.(P<0.05~0.01)
Think currently, the CCl4 passes to break liver cell and it inside film structure, hurt or kill liver cell, cause the Mao in the afterbirth syrup,such as ALT, AST etc., overflow to blood.Therefore, the ALT and AST level Gao Di can be hurt with sensitive ground reflection liver in the serum of degree.This experiment express that summer withered grass water lifts a thing to make small rat ALT and AST be worth to go up obviously and explain that the summer withered grass has the liver toxicity the function.Moreover, Fu basin son+ the CCl4, Yin go grass+ CCl4 and summer withered grass+ to compare with CCl4 set, CCl4 set ALT value and AST be worth to also have to obviously go up and the herb medicine can aggravate CCl4 liver harm in hint these 3 kinds.
The local data shows that winning the liver disease that the herb medicine cause occupies a not small comparison in the our country medicine liver disease.The foreign Chinese herbal medicine safety’s study is medium and Chinese herbal medicine liver’s injure is also a point to involve a contents.But the local cultural heritage most lay particular emphasis on report and summary of case currently, the research less of the Chinese herbal medicine safety, so should value the research and prevention and cure of the Chinese herbal medicine liver disease or liver injure.This experiment hints that the summer withered herbaceous body has the liver toxicity that can’t neglect, so should notice method of using, dosage in the clinical application, avoid causing the Chinese herbal medicine medicine source disease thus.Certainly, this time research only carried on first step understanding to the liver toxicity of summer withered grass, as to it’s the liver hurt mechanism and pathology change etc. need a further research.
Moreover win western medicine consociation an usage nowadays gradually widespread, the consociation application which wins western medicine reasonable can increase an effect or reduce poison, but not reasonable of the suitable for use may result in more bad reactions, include liver harm etc..This research announce to public, Fu basin son and Yin went a herbaceous body and influence to the small rat ALT and the AST, but aggravated small rat CCl4 liver to hurt, past should also value the poisonous reason that the consociation uses a medicine to learn a research
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